*Scroll down to the bottom of the article to find your discount code for ALL Cannacares CBD Products There are plenty of frequent ailments that will affect practically everyone eventually. From arthritis to aching knees, there are some things that are just a given when it comes to getting older. Easily one of the most CBD Vs Statins To Control Cholesterol While statins may lower your LDL cholesterol numbers, some researchers believe it does nothing to protect users from heart attacks or strokes. They also have
Can CBD oil treat high cholesterol levels?
There are plenty of frequent ailments that will affect practically everyone eventually. From arthritis to aching knees, there are some things that are just a given when it comes to getting older.
Easily one of the most prevalent of this list is cholesterol. This irritating and sometimes severely painful condition affects millions each year, and there are remarkably few options for those looking to try and treat it.
Some people are attempting to combine CBD and cholesterol in an effort to try and diminish their continuous cholesterol plague. But does it work?
Well, first of all, we need to learn what cholesterol is and how we can typically treat it.
What Is Cholesterol?
Cholesterol is commonly known as an evil, dangerous substance that ruins your life, no matter how much you have.
However, cholesterol is one of the most mischaracterized bodily substances that we know of today. Instead of being wholly terrible and dangerous, cholesterol is actually a vital part of our cells and health; without it, we wouldn’t be able to survive.
Cholesterol is used to help make all kinds of vital molecules in your bodies, such as your hormones and your ability to intake vitamins. It exists in all of your cells and is what enables them to function correctly.
While the precise cholesterol definition feels almost too confusing to understand, the actual function of cholesterol is far simpler.
Essentially, cholesterol is necessary for the production of so many things that your body needs to flourish. Furthermore, it helps to regulate membrane fluidity in different temperatures, something vitally important for healthy cell growth and maintenance.
The confusing aspect of cholesterol is that we treat it as having two different definitions based on its precise source. While cholesterol in the body is one thing, we treat dietary cholesterol as something entirely different.
Dietary cholesterol is the same thing in animals as it is in humans, except it matters to us because of how we digest it when we eat animals. It is necessary to eat a sufficient level of cholesterol to maintain health. But too much of it can put you in danger.
So, what are the exact causes of high cholesterol?
What Causes High Cholesterol?
To understand high cholesterol, we need to fully comprehend the different types of cholesterol.
Cholesterol is continuously flowing through your body by way of your blood cells. In your arteries, cholesterol attaches itself to proteins in the blood and gets transported to where it needs to be. This combination of the two is referred to as a lipoprotein, and they are further broken up into two distinct types of cholesterol.
Low-Density Lipoprotein: The first one, low-density lipoprotein, also known as LDL, is the typically maligned form of cholesterol. This type of cholesterol can build up in your bloodstream, causing blockages and reducing sufficient blood flow.
High-Density Lipoprotein: The other type, high-density lipoprotein, or HDL, is known as the generally healthy one. This form of cholesterol can help reduce your levels of LDLs and take them back to your liver.
VLDL: Finally, diabetes increases the production of an even more dangerous form of cholesterol known as VLDL, which can cause even higher risks of developing high cholesterol.
Getting older, being a diabetic, or smoking are also other everyday things that can increase your risk of developing high cholesterol. Smoking damages your blood vessels, and age makes your body less efficient at cutting down the levels of bad cholesterol.
The precise risk factors of having high cholesterol are primarily due to a few things; diet and a lack of exercise.
If you eat a diet that is particularly high in saturated and trans fats, then you are likely to suffer from a higher than acceptable level of cholesterol. Furthermore, being obese or weighing more than you should, in general, will also put you at risk of developing high cholesterol.
Exercise is an incredibly important aspect of keeping down cholesterol, as exercise helps encourage the production and retention of HDL, the generally good cholesterol.
What Is the Primary Source of Cholesterol?
So, this is where a good deal of the confusion regarding cholesterol comes in. All of the cholesterol that you actually need in your body is created in the liver. Any extra cholesterol floating around comes from the food you eat, such as fatty foods.
This latter form of cholesterol is referred to as dietary cholesterol, and it is the main thing you need to watch out for.
So what can kind of exciting things can you do to try and reduce your cholesterol? Can you use CBD to try and reduce it?
Does CBD Lower Cholesterol?
CBD oil is one of those things that has been used to treat all kinds of different and exciting medical conditions. But cholesterol is easily one of the oldest problems considered by cannabinoid users. There is a substantial amount of evidence showing that CBD oil could help reduce cholesterol and overall improve your heart health.
Various studies, such as this one by Stanley et al. for the British Journal of Clinical Pharmacology, have found that CBD oil and cholesterol go together exceptionally well. That is, CBD is able to help improve your heart health and overall help treats high cholesterol.
Interestingly though, the answer to the question of ‘can CBD oil lower cholesterol?’ is, oddly enough, no. It isn’t that it can lower your cholesterol, but instead that it can help improve your heart health in general. This has the side effect of effectively lowering your cholesterol and improving your overall health.
But first, what kind of treatment options are available before considering CBD oil? How do doctors traditionally treat cholesterol with conventional medicine?
The two options for cholesterol treatment are either to attempt to try and remove excess LDL cholesterol through medication or to try and improve general heart health.
Different drugs perform these effects in different ways; it all depends on the severity of cholesterol and what level of risk your high cholesterol presents.
Considered the mandatory drug for everyone over the age of 50, statins are an effective way of controlling your cholesterol production. They substantially slow down the production of cholesterol in your liver. They also actually help your body to reabsorb any extra cholesterol that is hanging around in your body.
This means that it not only acts as an effective treatment option, but it can also partially reverse any severe heart afflictions you are suffering from.
The issue is that there are some side effects with taking statins, as well as just generally being annoying because you have to take them every single day.
Bile Acid Binding Resins
This treatment option is a bit of a tricky one because it seeks to lower cholesterol production indirectly. One of the primary uses of cholesterol is in making something called bile acids, which are needed to help encourage healthy digestion.
This group of medications, called bile acid-binding resins, bind themselves to bile acids in your body, tricking your liver into thinking you don’t have enough of them. This forces your liver to reroute excess cholesterol into trying to make them, forcing the cholesterol out of your blood and using it up.
This can, of course, induce digestion troubles, but that is far and away preferable compared to suffering from coronary heart disease.
Cholesterol Absorption Inhibitors
One of the main ways that dietary cholesterol enters your body is through the small intestine, where it absorbs plenty of it from your food. This group of drugs slows down the rate at which your small intestine can absorb cholesterol from your food.
The main benefit of these substances is that they are combined with other drugs, like statins, to attempt to try and create a combined effect. On their own, they don’t reverse anything. But merely act as a stopgap to limit the results for the future.
Injectable medications are a broad category, but fundamentally, they are focused on lowering the amount of cholesterol that is free in your blood.
These are ideally used for genetic conditions, such as those with diseases that create adverse levels of cholesterol. They effectively encourage your liver to absorb and remove more LDL than it would normally.
This requires frequent injections and continuous medical checkups to ensure they are working correctly, which can be a real pain.
But what about CBD oil? How could CBD oil help cholesterol?
CBD Oil and Cholesterol
CBD oil is a particularly interesting medical substance because it has effects throughout the body. This is due to how it impacts the endocannabinoid system.
The critical thing regarding how CBD oil can help cholesterol is the fact that cholesterol is, fundamentally, a fatty cell. CBD has been shown to not only help regulate all manner of different bodily functions but also how much cholesterol is maintained in the body.
You can use CBD oil as a surprisingly effective cholesterol treatment option, just by remembering to take a dose every day.
However, the primary way that CBD and cholesterol work together is due to CBD’s vascular relaxant properties. When you take CBD, it is able to help reduce your blood pressure by relaxing the arterial walls running throughout your body.
This happens because as a result of CBD’s interaction with the CB1 receptor and is a great way to help reduce excess cholesterol. As the arterial walls relax, your blood pressure is reduced, and your heart doesn’t work as hard to pump blood around the body.
Consequently, this helps ease and reduce the level and intensity of cholesterol blockages, as your body has more time to get rid of them.
Final Thoughts on CBD Oil and Cholesterol
When trying to answer the question of ‘can CBD oil lower cholesterol?’, the issue is that the answer isn’t quite as straightforward as you might have first thought.
CBD and cholesterol clearly have a well-established link to one another, but to outright say that CBD oil reduces cholesterol directly wouldn’t be entirely true. Instead, it is more the case that CBD oil can help to encourage the gradual lowering of your cholesterol levels. At the same time, it can help ease blood pressure and improve your overall health.
Both of these latter qualities are what make it so multipurpose and useful, as it is not only potentially effective as a treatment for cholesterol, but also for many other things.
The key thing to take away is that, while CBD can indeed help with excess cholesterol, it is not an emergency, completely fool proof curative. If you are suffering from serious cholesterol issues, the best thing you can do is go to your doctor and get it seen to.
CBD Vs Statins To Control Cholesterol
While statins may lower your LDL cholesterol numbers, some researchers believe it does nothing to protect users from heart attacks or strokes. They also have many adverse side effects which may lead to long-term problems in the future. Studies suggest that CBD may lower blood cholesterol levels and remove plaque. In this article, I will discuss how statins work, list their adverse side effects, and explain the importance of cholesterol. I will cite studies that support the potential replacement of statins with CBD as well as further studies about possible CBD-statin interactions.
What Are Statins?
Statins are a class of drugs that reduce the blood lipid levels by changing the activity of the liver enzymes in their production.
Statins Side Effects
- May cause muscle damage
- May cause neurological problems
- May increase blood sugar levels
- May cause liver damage
The Importance of Cholesterol
Some people view cholesterol as bad. But, a substantial amount of cholesterol, a waxy fatty acid found in human cells, is required by the body to carry out essential functions. These include the production of hormones, vitamin D, digestive bile, and the maintenance of many brain functions. HDL is the good cholesterol and LDL is the harmful cholesterol.
The human body stores cholesterol for future use, but when there is an excess of cholesterol, it gets stored in the arteries. The HDL is used for necessary bodily functions, but the LDL turns into plaque in the arteries. Plaque buildup is what leads to heart disease and strokes. However, statins do not actually remove plaque. They simply block the cholesterol producing enzyme, HMG, which reduces the total amount of cholesterol in the bloodstream. This forces the body to reabsorb the cholesterol from the arteries.
Many studies suggest that an increase in HDL and a decrease in LDL may lead to a decrease in cardiovascular mortality. Some of the more recent studies suggest that there is no correlation between a higher LDL cholesterol number and the development of cardiovascular disease.
Can CBD Effectively Replace Statins?
While CBD is known for many therapeutic effects, there are few studies suggesting its impact on the removal of plaque and the reduction of LDL. Here are a few that do support this hypothesis:
- Hector Lopez led a study, published in May 2020 in the Journal of Dietary Supplements, that suggested that CBD may increase HDL levels through its impact on specific brain receptors.
- A 2016 study, published in Diabetes Care, indicated that CBD may regulate the production of insulin and metabolism of sugar and increase the capacity to process unhealthy fats. This process was seen to lower the LDL levels in overweight, but otherwise healthy individuals, within six weeks, even with a normal diet.
- A 2013 study, published in the British Journal of Clinical Pharmacology, showed that CBD oil may indirectly regulate blood cholesterol content and reduce cardiovascular disease risk by minimizing the stress response by the cardiovascular system.
While there is still no agreement by researchers on the effect that CBD has on the heart, here are some studies promoting the supposition that CBD may have cardi-protective properties:
- A 2010 study, published in the Journal of the American College of Cardiology, suggests that CBD may prevent heart attacks and other cardiovascular diseases in diabetic patients.
- A 2020 study, published in the Journal of Dietary Supplements, demonstrated that CBD may regulate the immune system and provide cardiovascular protection through its indirect activation of CB2 receptors by way of the 5-HT3A brain receptor.
- A 2019 paper, published in the Recent Advances in Cannabinoid Physiology and Pathology, makes the case that there is a close link between the endocannabinoid system (ECS) and its impact on cardiovascular diseases. CBD may act as a vasorelaxant, which allows more blood to flow through blood vessels. This reduces the stress on the heart.
Scientists are unclear on how CBD interacts with statins. Studies indicate that CBD inhibits several of the liver enzymes which are necessary for breaking down statins. The outcome may be an increase in the concentration of statins in the bloodstream approaching toxic levels. With long-term use, this could mean a risk to a patient’s health including more adverse side effects.
Here is what we know:
- Statins are metabolized by the liver’s Cytochrome P450 group of liver isoenzymes; CYP3A4, CYP3A5, CYP2C9, and CYP2C19
- Studies indicate that CBD inhibits these enzymes
- Long-term use of CBD can interfere with the normal functioning of these enzymes, thus lowering the blood statin clearance rate
- This causes higher concentrations of statins remaining in the bloodstream, leading to an increase in the severity of side effects
- While there is no conclusive evidence that combining CBD with statins is harmful, the aforementioned information suggests that it poses a possible health risk.
Here are a few publications which show the impact of combining CBD with statins:
- The March 2020 edition of the Pharmacist’s Guide to CBD Oil, suggested that CBD has the potential to reduce the effectiveness of statins by inhibiting the CYP3A4 liver enzyme.
- A 2020 study, published in the Canadian Medical Association Journal, found that certain other medications may cause an increase or decrease of CBD which may affect its impact on other drugs.
Anecdotal evidence shows significant interactions of the two medications only in rare cases of long-term usage and high doses of both. Clearly, if you notice any drug interactions, consult your physician.
Pharmacologists Waiting for Patent on a Cannabinoid-Statin Medication
Colorado-based pharmacology inventors, James Smeeding and Mathew Sherwood, of Indication BioScience, have developed a medication combining a cannabinoid with a statin and are awaiting patent approval.
Their findings indicate that the use of cannabinoids may increase the efficiency of the ECS. The fact that they have developed this medication suggests that their risk/benefit assessment of a potential interaction must be quite a low risk. However, in order to satisfy the FDA, it seems reasonable to conclude that more human clinical trials will be required.
Let us hope that the use of cannabinoids plays a major role in the future of cardiovascular therapies or at the very least, may be used to relieve some of the symptoms of cardiovascular diseases.
thecannabisradar.com, CBD & Statins: Can CBD Replace Statins as Cholesterol Medication?