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de Meijer, E. P. M., and Hammond, K. M. (2005). The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants. Euphytica 145, 189–198. doi: 10.1007/s10681-005-1164-8

Takeda, S., Okajima, S., Miyoshi, H., Yoshida, K., Okamoto, Y., Okada, T., et al. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol. Lett. 214, 314–319. doi: 10.1016/j.toxlet.2012.08.029

Table 2. Semi-quantification of the identified cannabinoids.

Discussion

Figure 9. One-way ANOVA test of the ten hemp seed oil samples. Red points indicate statistically significant features, green points indicate features that do not contribute to the statistical difference (adjusted p-value cut-off: 0.01, post hoc test: Tukey’s Honest Significant Difference test).

Citti, C., Pacchetti, B., Vandelli, M. A., Forni, F., and Cannazza, G. (2018c). Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA). J. Pharm. Biomed. Anal. 149, 532–540. doi: 10.1016/j.jpba.2017.11.044

Figure 5. HRMS fragmentation spectrum of cannabigerol (CBG) in positive (A) and negative (B) ionization mode.

In the present work, we report the identification of 32 cannabinoids in 10 commercial hemp seed oils obtained by organic farming. Of these, 9 cannabinoids were identified with level 1 annotation, using the corresponding analytical standards, and 23 were putatively identified with level 2 annotation, according to exact mass and mass fragmentation match with standards found in the database mzCloud and/or reported in the literature (Salek et al., 2013). It is noteworthy that for the first time a number of cannabinoids, which to the best of our knowledge have never been reported, have been identified in hemp seed oil.

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Date and time: Thu, 24 Jun 2021 09:16:02 GMT