Posted on

cannabis lsa seeds clusterbuster

Based on his first study Andrew Sewell conducted a more elaborate research in 2008. This time he investigated whether LSA has a similar effect. LSA is (amongst others) found in the seeds of Hawaiian baby woodrose and Morning glory. Like LSD it has a consciousness expanding effect. 367 cluster headache patients participated in this study. Again the results were remarkable. Of all participants 56% responded positively to LSA. Furthermore it became clear that the dosage level on which LSA works is very low. It is sufficiently low that there occur no to barely any consciousness expanding effect. So, if cluster headache patients want to experience the beneficial effect of psychedelics, they do not necessarily have to trip, which in some cases is desirable.

This is a very complicated situation. For a large amount of cluster headache patients (a very low dose of) psychedelics is their last resort, but they are not allowed to take it. In the Netherlands the law is not too strict, and many patients treat themselves successfully with psychedelics. In the United States the situation is different: you can end up in jail when caught using LSD. This holds for cluster headache patients as well. The fact those people have no choice but suffer, only for reasons of legislation, is of course ridiculous.

Luckily there is good news: it turns out there is a treatment that is safe, works in most patients, and of which the effects persist for months, even after one single dose. It might sound unbelievable, but many cluster headache patients treat themselves successfully with psychedelics.

Cluster headache can cause severe agony: to such an extent that some patients suffering from the disease see no other solution than ending their life. That is why it is sometimes called the suicide headache. The pain of an attack is described to be more violent than the amputation of a limb without anaesthesia. Therefore it seems logical that the quest for a good medicine is urgent.

Based on Sewell’s results a new study was started in 2010, this time guided by Matthias Karst and John Halpern. In the course of this research the substance BOL-148 was used. The substance is derived from LSD, but has no consciousness expanding effect whatsoever. The drug was administered to four patients with chronic cluster headaches; three of them were pain-free for months. The other participant experienced a large improvement.

In order to prove the effects of psychedelics, researcher Andrew Sewell conducted a pilot study in 2006. 53 cluster headache patients took psilocybin or LSD. The results were remarkable: with 84% of the psilocybin-users and 88% of the LSD-users an attack stopped completely. This is very remarkable, as no other medicine showed similar effects. Furthermore about 80% of the patients stayed pain-free for months after one single dose. How it is possible that one single dose can prevent attacks for months is still unclear, but the research elicited hope on a pain-free life for many cluster headache patients.

Maybe you now think: ‘there exists a potential effective treatment for cluster headache patients: they must be investigating this thoroughly.’ Unfortunately things are a bit more complicated. Despite the fact that BOL-148 has no hallucinogenic effect at all, and there are no indications that the drug will be toxic in low dosages, its use is not approved by the FDA. It is a mystery why the substance is prohibited, but the status quo makes it very complicated to start a larger research project into the beneficial effects of BOL-148.

When using psilocybin, LSD, or DMT as an acute treatment, it was sometimes said to intensify pain and other symptoms initially, before any mitigating or preventative effects on CH or migraines were noticed: “I thought that the mushrooms hadn’t helped and I was back to where I started. But I haven’t had a headache since that night.” Psilocybin use was occasionally reported to cause anxiety or panic attacks. On the other hand, these adverse effects were also described as manageable by a more infrequent dosage interval by some of the same users: “I found that if I didn’t take shrooms more than once a month, I didn’t get anxiety.”

The sample being self-selected and non-randomized may contribute to some bias, and the accuracy of individual reports cannot be guaranteed. However, the described effectiveness of psychedelic tryptamines does not appear to be based on selective reporting or drug romanticism. If skewed reporting was the culprit for the results, we suggest that the same would be presented for the uses of cannabis where the treatment results were reported as highly varying. Information on dosage was sometimes ill-defined or missing. Also, the purity or concentration of ingested materials is unknown. Therefore, the connection between dosage and effects could not be further elucidated in the present study.

A few published studies [10, 16] and rich anecdotal supports also indicate the effectiveness of cannabis for alleviating headaches, but to our knowledge, no proper clinical trials are currently available. Historically, cannabis was well-regarded as an acute, as well as prophylactic, treatment for headache disorders and was included in the major pharmacopeias of the second half of the nineteenth century [10]. The illegal status of cannabinoids and psychedelics has critically hindered medical research, and there are currently no blinded studies on headache patients so true effectiveness can be determined [10]. To improve understanding of the effects and possible benefits or harms of scarcely researched substances, Internet discussion forums, and the users’ own accounts of their experiences, have proven to be a valuable source for surprisingly accurate early research data when clinical trials are not available [17,18,19,20,21,22].

Effects and treatment results

No severe adverse effects were reported, but there were some accounts of discomfort and temporarily increased symptoms and also some possible cases of remaining anxiety.

The dosage of LSA seeds was not extensively discussed, but it was suggested that around 50 seeds were needed for a full preventative dose, although it appeared more common to use less than 25 seeds and more frequently, following a dosing regimen. Mostly, the seeds were ingested whole, but occasional reports used various techniques to extract the active substances.

The data contained a few discussions on various routes for administrating psilocybin, some suggested sublingual administration (ground up mushrooms under the tongue), and others preferred to mix the mushrooms with water or juice for drinking.

Cannabis was commonly discussed for its potential to alleviate symptoms or lessen the frequency of migraine attacks. Some had used cannabis for unrelated purposes but experienced additional benefits on the headaches.

I’m not sure how it first came about to be used for CH. It was a common sense conclusion to try it for CH, since it is an indole ring hallucinogen, very similar to psilocybin and LSD. It’s not really new here. It has been over a year since someone first posted here that LSA worked for CH. I’m not sure why it became popular recently.

I’m lying on the couch awake all night cuz of surgery on both knees for AVN – apparently a combination of my own biology but progressed/accelerated by taking prednisone. I never knew steroids could do that until I was diagnosed. In fact, I never even knew what AVN was. But at the same time, not everyone who takes steroids gets AVN. How can we ever know for sure who will wind up with what bad effects from whatever treatment we choose? It’s a scary thing.

There is some information on LSA and HBRW seeds at

For medicinal purposes, Flash is recommending a conservative approach of starting off with a single HBWR seed for the first dose, then increasing that to 2 if there is no anti-cluster effect, then 3, etc.

While realizing that anyone trying this is acting as a guinea pig, I would have a serious concern about the dosage. Some say 4 seeds. some say no more than 12. I’m 5′ tall and weigh 105. Wouldn’t that be a factor in how much I should take? A man who is 6’2" would tolerate a lot more than I would.